Skip to main content

Drug Resistance Tuberculosis

Overview

Together with the South African KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) and our colleagues in the IBM Research lab in Melbourne, we are studying new treatment and diagnostic approaches to fight tuberculosis (TB) in South Africa. In this study we are analyzing drug susceptibility tests and TB genomes, each with 4.4 million base pairs, to better understand the complex clinical picture of African tuberculosis infections. Towards this end we employ a full analysis pipeline starting from the raw sequences all the way to advanced modeling techniques to pinpoint small and large genomic alterations in the course of TB evolution that are associated with changes in drug resistance.

For more information see press release.

Reference: Paradoxical Hypersusceptibility To Beta-Lactams In Drug Resistant Clinical Isolates Of M. Tuberculosis: Elucidation Of Molecular Mechanisms By Whole Genome Sequencing, ATS 2014.

Contact: Tal El Hay