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BIOINFORMATICS AND INFORMATION-BASED MEDICINE:
FROM PHARMACOGENOMICS TO PERSONALIZED HEALTHCARE

The Fourth Bioinformatics Industrialization Workshop for industrial-strength integration, automation, simulation, privacy, quality and standards in medicine and the high throughput life sciences, cosponsored and organized by IBM Life Sciences, The Deep Computing Institute, IBM Research, The International Union of Pure and Applied Biophysics, and the Program in Biological and Medical Informatics, University of California San Francisco - Genentech Hall, University of California San Francisco, December 6-7, 2003.

Directions to the new UCSF Mission Bay campus

MAP: http://www.ucsf.edu/campuses/maps/mb.pdfs

HOTELS: Marriott Courtyard: Lisa Johnston: 650-837-9000 SF airport or Eric Lopez: 415-486-6463 downtown SF.

What to do in San Francisco in your spare time: http://www.sfgate.com/eguide/

Spaces are available at the above symposium concerning the union of medicine with information technology and genomics to enable sophisticated public personalized health care in the near future. The first meeting “Bioinformatics Comes of Age: Using the Genome” was held at the Whitehead Institute Cambridge Mass., and opened in 2000 on the day of the announcement from Washington DC on the completion of the first draft of the human genome projects. Subsequent meetings on “Bioinformatics and Medicine” were held at the Wellcome Trust Campus and the European Bioinformatics Institute, UK. The symposia were also Workshops to help the Inter-Unions Bioinformatics Group and the International Union of Pure and Applied Biophysics prepare a Report for UNESCO and the ICSU. This is completed but selected persons may stay a further day of the 2003 meeting to collate material for a white paper. Prestigious speakers include Russ Altman of Stanford University, Bruce McManus of the University of British Columbia, William Knaus of Virginia University, William Evans of St. Jude Children's Research Hospital, Larry Gelbert of Eli Lilly, Sharon Marsh of Washington University, Kathy Giacomini of the University of California San Francisco, Jean Garnier, President of the International Union of Pure and Applied Biophysics, Lee Edwards of Imperial College and the Clinical Data Recorder Group, St Mary’s Hospital, London, and Carlos Caldas of the Hutchison/MRC Research Center, Cambridge UK.

Applications.

The meeting fees are: $500 for industry representatives, $150 for participants from academic and not-for-profit institutions. Attendance is limited to 260 people, including speakers. Participants should make their own arrangements for accommodation. The deadline date for receipt of fees under normal circumstances is now November 21st 2003, though, if there are places, special requests are considered. There can be no refund for cancellations although an appropriate substitute in your place is normally acceptable. Whereas we believe the program below to be final, unexpected circumstances may necessitate changes. Please make checks out to "UC REGENTS" and mail to:

UCSF Office of Research
c/o Terry Dong
513 Parnassus Avenue, Room S-101
San Francisco, CA 94143-0407


Other inquires and the special requests on late submission should preferably be made by e-mail to the following. For applicants from the United States: Barry Robson, c/o Laura Soleng, T. J. Watson Research Center, Route 134, 1101 Kitchawan Road, Yorktown Heights, NY 10598 USA; Tel: 914-945-2079, Fax: 914-945-4597, soleng@us.ibm.com. For applicants outside the United States: Jean Garnier, INRA - Unite MIG (Mathematique Informatique et Genome), Bat. 233, Domaine de Vilvert, 78352 Jouy en Josas Cedex, France; Tel. : 33.(0).1.34 65 28 84 or 28 86 (sec.), Fax : 33.(0).1.34 65 29 01, jgarnier@jouy.inra.fr

For applicants from the United States:
Barry Robson,
c/o Laura Soleng,
T. J. Watson Research Center,
Route 134,
1101 Kitchawan Road,
Yorktown Heights, NY 10598
USA;
Tel: 914-945-2079,
Fax: 914-945-4597,
Email: soleng@us.ibm.com.

For applicants outside the United States:
Jean Garnier,
INRA - Unite MIG (Mathematique Informatique et Genome),
Bat. 233, Domaine de Vilvert, 78352 Jouy en Josas Cedex, France;
Tel. : 33.(0).1.34 65 28 84 or 28 86 (sec.),
Fax : 33.(0).1.34 65 29 01,
Email: jgarnier@jouy.inra.fr

_____________________________________________________________
PROGRAM

Saturday 6th, a.m. Building and Using Collective Achives of Pharmacogenomic Data (1)

10.15 a,m.
Welcome from the organizers


10.30-11.30
“Keynote speech: Building and Using Pharmacogenomic Data”
Russ Altman, Stanford University School of Medicine

11.30-12.30
"The challenges of the smaller company in the medical bioinformatics and information-based medicine space"
Vincent Stanton, entrepreneur

12.30-1.00
“Architectures for secure acquisition and use of patient data”
OK Baek, Life Sciences IBM Canada

Saturday 6th, p.m. Building and Using Collective Achives of Pharmacogenomic Data (2)

2.30 – 3.30
“Polymorphic Protein Sequence, Structure and function data. The Example of Population Genomics and HLA Structural Polymorphism in the response to Natural and Malicious Biothreat.”
Christian Parry, University of Massachusetts Medical School.

3.30-4.30
“Gene Expression study case. Global gene expression in human tumors: childhood
acute lymphoblastic leukemia as a paradigm”
Williams Evans, St. Jude

4.30-5.00
THE DIRAC FOUNDATION LECTURE
“Mining High Dimensional Clinical and Pharmacogenomic Data: New Approaches and Unexpected Help in the Mathematics of Riemann and Dirac.”
Barry Robson, T. J. Watson Research Center (IBM)
(These lectures are given annually by members of The Dirac Foundation to honor and promote Professor Paul A. M. Dirac’s humanitarian interests and his contributions to the theoretical foundations of physics, chemistry, biology and medicine. The Dirac Foundation is based at St Mary’s Hospital, Imperial College, London.)

5.00-5.30
SPECIAL IUPAB REPORT
Report of the Inter Unions Bioinformatics Group (IUBG) on biological databases
Jean Garnier, Chair, International Union of Pure and Applied Biophysics

Sunday 7th, a.m. Research Applications: Building Knowledge of Pharmacogenomics and Drug Metabolism

9.00-10.00
“The Pathways Approach to Pharmacogenomic Studies”
Sharon Marsh, Washington University School of Medicine

10.00-11.00
“Drug Transporter Variants”
Kathy Giacomini, University of California, San Francisco

11.00-12.00
“Chips, SNPs, Genes and Drugs: A New Drug Discovery Paradigm for Personalized Medicine"
Larry Gelbert, Eli Lilly

12.00-1.00
“Pharmacogenomics of Pulmonary and Cardiovascular Disorders”
Stephen Liggett, University of Cincinnati

Sunday 7th , p.m. Healthcare Applications; The Patient’s Digital Clinical and Genomic Record.

2.00-3.00
“The Digital Patient Record”
William A. Knaus M.D., Department of Health Evaluation Sciences University of Virginia School of Medicine

3.00-4.00
“Construction and Use of the Digital Record of the Cancer Patient
Carlos Caldas, University of Cambridge, Hutchison/MRC Research Centre, Cambridge

4.00-4.30
“Information-Base Medicine: Examples Including the NHS Initiative”
Haim Nelken, IBM Research, Haifa

4.30-5.30
“Second by Second: Clinical Safety and Patient-Clinical Transaction History in the Information-Rich Digital Patient Record”.
Lee Edwards, St. Mary's Hospital, Imperial College, London

5.30-6.30
“Keynote Speech: The Physician-Reseracher and Patient Data: Hunting Down the Origins and Cures of Cardiovascular Disease”
Bruce M. McManus, University of British Columbia, iCAPTUR4E, and the Centre Institute of Circulatory and Respiratory Health, Vancouver

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