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2.1- Deterministic Approximation

It is often the case that a deterministic analysis can provide a reasonably accurate picture of many aspects of the dynamics of an epidemic [27], [32]. For the sake of simplicity, we shall assume that the infection rate along each edge is tex2html_wrap_inline1320 and the cure rate for each node is tex2html_wrap_inline1322 . If the population N is sufficiently large, we can convert I(t), the number of infected nodes in the population at time t, to tex2html_wrap_inline1330 , a continuous quantity representing the fraction of infected nodes. Then, if we assume that the details of the graph's connectivity are fairly unimportant, the dynamics of infection depend only upon how many nodes are infected (rather than which particular nodes are infected). Later, in section 2.3, when we use simulations to test the validity of this assumption, we shall find that it works well when there are many edges in the graph but fails miserably when there are only a few edges per node.

Now consider a particular infected node. Since the expected number of edges in the graph is pN(N-1), the expected number of edges emanating from this node (which we shall refer to as the connectivity gif) is tex2html_wrap_inline1334 . The fraction of neighbors that are susceptible to infection is 1-i, so the expected number of uninfected nodes which can be infected by this node is tex2html_wrap_inline1338 . Therefore, on average we expect the total system-wide rate at which infected nodes infect uninfected nodes to be tex2html_wrap_inline1340 , where tex2html_wrap_inline1342 is the average total rate at which a node attempts to infect its neighbors. The system-wide rate at which infected nodes are cured is simply tex2html_wrap_inline1344 . By ignoring stochastic variation in the number of branches emanating from each node and in the average infection and cure rates, we obtain a deterministic differential equation describing the time evolution of i(t):

 

equation141

The solution to Eq. 1 is:

 

equation148

where tex2html_wrap_inline1348 is the average ratio of the rate at which an infected node is cured to that at which it infects other nodes, and tex2html_wrap_inline1350 is the initial fraction of infected nodes.

If tex2html_wrap_inline1352 , the fraction of infected individuals decays exponentially from the initial value tex2html_wrap_inline1354 to 0, i.e., there is no epidemic. If tex2html_wrap_inline1356 , the fraction of infected individuals grows from the initial value tex2html_wrap_inline1358 at a rate which is initially exponential ( tex2html_wrap_inline1360 ) and eventually saturates at the value tex2html_wrap_inline1362 . This result has a simple intuitive interpretation: if the average number of neighbors that an individual can infect during the time that it is infected exceeds one, there will be an epidemic; if this number is less than one, the infection will die out. The existence of this threshold was first established for homogeneous interactions by Kermack and McKendrick [27] in the 1930's, and here we will show that it holds for directed graphs as well. According to this deterministic result, all that matters is the total rate tex2html_wrap_inline1364 at which an infected node transmits infection to other nodes -- not the details of how it distributes that infection.


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